R-Lipoic acid is the form best utilized by the body, bound to sodium, providing it in its most stable absorbable form.
Studies indicate that supplements containing only R form appear to be better absorbed than supplements containing both R- and S- forms, with results showing twice as much ALA appearing in the bloodstream after an oral dose of R-ALA.
- Alpha-lipoic acid occurs naturally as a 50/50 mixture of R-ALA and S-ALA. R-lipoic acid by itself functions as an essential cofactor for many enzymes involved in energy production.
- It also has characteristics, including significant antioxidant effects, that contribute to liver, brain, nerve and eye health.
- Alpha-lipoic acid, also known as thioctic acid, was discovered in 1951 as a molecule that assists in acyl-group transfer and as a coenzyme in the Krebs Cycle. In the 1980s, the scientific community realized that alpha-lipoic acid is also a powerful antioxidant.
- What sets ALA apart from other fatty acids is that it’s an antioxidant in both fat- and water-soluble environments and it’s also an antioxidant in both its oxidized and reduced forms.
- ALA also increases intracellular glutathione and CoQ10 levels.
- Promotes normal protein glycosylation and inhibiting the enzyme aldose reductase, which in turn inhibits conversion of glucose to sorbitol.