MotilPro supports serotonergic and cholinergic neurotransmission in the G.I. tract.
5-HTP is absorbed by enterochromaffin cells in the epithelium, in which it is decarboxylated to serotonin using pyridoxal 5′ phosphate as a cofactor.
- 5-HTP stimulates enteric neurons through activation the of 5HT4 receptors.
- Ginger modulates serotonin signaling by additional 5HT4 stimulation and by binding type 3 (5HT3) receptors in the enteric nervous system and brain stem, supporting gastric emptying, intestinal transit, healthy visceral sensation, and upper G.I. comfort.
- Acetyl-l-carnitine supports autonomic neuronal health and contributes acetyl groups for the synthesis of acetylcholine, supporting neurotransmission of signals to encourage healthy motility.