Regulation of glycation is an active constituent of many plants including Phellodendron amurense root. Berberine activates adenosine monophosphate kinase (AMPK). AMPK is activated through various mechanisms including exercise to support glucose metabolism via an insulin-independent mechanism. Berberine has been the subject of human, randomized placebo-controlled trials.
These plants have been used in traditional Chinese and other herbal medicine systems for centuries. More recent characterization and isolation of the main active constituent, berberine, has led to the development of this Berberine hydrochloride supplement.