Oxidative stress is an imbalance of free radicals and antioxidants in your body. Free radicals are created when you experience physical stress, emotional stress, or chemical stress and they need to be quenched by antioxidants like Glutathione to filter thought your body. When the free radicals are so high with not enough antioxidants to reduce it, an imbalance occurs which is called Oxidative stress. Over time, oxidative stress puts a burden on your body to deal with and your body is not equipped to deal with it.